I, too, have battled SIBO. Before I had a breath test to confirm SIBO from a very skilled gastroenterologist, I was treated with a rotation of all kinds of antibiotics that did me no good at all. In fact, I think I got worse. When I'd had enough of the rotation of useless antibiotics, I changed doctors, he ordered a breath test for SIBO which confirmed that I did have it. I took Xifaxan for about a month. It worked. The SIBO was gone. But I have to work to keep it at bay. I also went on a very strict diet to reduce the growth of bacteria in my small intestine. All of this was about 5 years ago, and I remain on the diet to this day. Once you get rid of SIBO, you have to work to prevent its return. My diet: as little sugar as possible--this is so important, no sugar substitutes, no gum, no mints, nothing carbonated at all--includes soda, beer, or fizzy alcoholic drinks--all that does is encourage the bad bacteria growth in the small intestine. I eat reasonably--a healthy diet, LOTS of water every day. I don't cheat on the sugar with desserts. I haven't had cake, pie, cookies, ice cream, etc. since I got the SIBO under control. I do eat fruit in moderation and not frequently. I hope this helps you. Sounds like you have some other medical issues. Don't neglect them either. I wish you the best.