@wpprescott
I did fulfurinox most of 2022 prior to my pancreadectomy and liver resection. NED for about 6 months then a small spot showed up. When on Gem/abraxane. For me, a KRAS G12D, TP53 patient, it has minimal results but got me to an ablation to remove spot about 4 months later.

NED again for about 7 months. Then did RM 6236/9805 phase 1 trial. Effective for about 6 months until progression at my liver resection area. Interestingly, once off that and new scans, a pulmonary embolism and small spot showed in my lung. SBRT eradicated it (was it even cancer?). Now working on liver spot with Naliri and just finished SBRT.

I share all of this to wonder has anyone figured out which drugs are better for KRAS G12D? Gem or Folfuri?? Or is it the oxy/cisplatin that does the trick?

I am also at a crossroads and will be meeting with 3 noted doctors over the next few weeks. I would suggest you speak with Dr Kamgar at Wisconsin. I met her at a Seena Magowitz event and she was very impressive and doing some creative approaches that seem to have great validity with repurposing drugs already FDA approved.