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PSA Rise After ADT

Prostate Cancer | Last Active: Sep 11, 2025 | Replies (7)

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UPDATE:
I'm the original poster/starter of this discussion.

I had labs today-- the first time (2 months after) discontinuing 2 1/2 years of ADT (Orgovyx) following prostatectomy and radiation.

My PSA is still undetectable at < 0.01 as it has been for over 2 years now. My MO says taking PSA every 3 months in sufficient. I didn't want to come off ADT but he's convinced me that longer term ADT is not good and if my PSA starts to rise, we'll attack it then.

No PET is planned unless PSA starts to rise. I do have a lung CT scan coming up in a few months-- keeping a eye on a small (< 6mm) lung nodule that appears staple for 1 1/2 years. MO says not likely metastasis because soft tissue metastasis usually occurs only after bone.

I live in a small town with a small town but well-respected hospital/medical community. I get scared sometimes but I feel I'm in good hands for now. My MO today told me to stop worrying about things I can't control.

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Replies to "UPDATE: I'm the original poster/starter of this discussion. I had labs today-- the first time (2..."

That's awesome news man! Listen to your doc, they know. Even if your PSA starts rising again, they have plans. Best of luck, brother!

Doug