My husband, age 79, was diagnosed with Alzheimers two years ago after having an MRI as well as a lumbar puncture that revealed amyloid matter in his spinal fluid. He has been taking the same medications that your significant other is taking. He began Leqembi treatment shortly thereafter but stopped after six sessions because he felt the risk of brain bleeds wasn't worth the slight slowing of progression of the disease. This past June, he also had a blood test that confirmed he had one copy of the APOE4 gene variant, which does raise the risk for Alzheimers somewhat. However, a subsequent PET amyloid scan didn't show amyloid matter and didn't confirm the Alzheimers diagnosis! So when we met with his neurologist two weeks ago, he changed his diagnosis to "mixed dementia of frontaltemporal dimension with some Alzheimers characteristics." (As my son, who is in the medical field, said, these diagnoses from doctors about dementia tend to be rather "squishy.") Anyway, it was at that meeting that I brought up the possibility of my husband starting on the 5 mg of lithium orotate, based on an article my son had forwarded to me and subsequent comments on the Mayo website. The neurologist agreed he should go ahead and try it. Let's hope that the dementia progression in both my husband and in your loved one is reversed. One can only hope!