I wish researchers, doctors, or someone would collect data on who had acute phase reactions and who didn't, as well as who followed the protocol for prepping for the infusion and who didn't. I think there are many here who were not properly informed of how to minimize those reactions. My endocrinologist knew about the water and Tylenol but had no idea about taking Claritin or an equivalent. I learned that from this group and am so grateful. The infusion nurse thought 30 minutes would be fine, and I said no to that...too short...and she did 45. There seems to be a huge disconnect in the medical community regarding how the Reclast infusions should be done.