After my first infusion, I was very sick with flu-like symptoms. However, I just had my second infusion, and exactly as the drug company information said, my side effects this time were minor and not worrisome. I would not hesitate to do a third. The nurse ran saline before, during, and after the Reclast and set the Reclast for 45 minutes. I was super hydrated and had taken Zyrtec and Tylenol before. I continued to take Tylenol for a few days. Note, I have Mast Cell syndrome and react very easily and this time, as I said, I reacted very little.