I too have tried Botox, helped at first but hasn't helped the last time done at all. I have been dealing with daily headaches and frequent migraines for 40 years. I have tried so many medications with no relief. Relpax does help sometimes. I am currently on day 5 of migraine, went for tornado shot and phenergan at urgent care, helped for a few hours but awoke with severe pounding headache again. I have been approved for SSDI thankfully as it makes it so hard to work with continuous migraines (as well as back issues). I have have been to multiple doctors, pain specialist, etc. might see about getting appt at Mayo to see if they can make any suggestions to get relief.