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jeff Marchi avatar

Issues with ProACT incontinence value

Prostate Cancer | Last Active: Sep 21, 2025 | Replies (27)

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Thanks Jeff for your comprehensive reply including your comments on bipolar ( beside my prostate cancer I’ve been DX as being BP However, I’ve had way more doctors tell me that they think I was misdiagnosed ( an interesting story for another place another time ) I like the way you explained your thoughts about not being a candidate for radiation. That thought fits perfectly into my complaints that since days one NO DOCTOR ever mention “ a stage “ nor have they explained 80% of what I learn here from all of you who politely remind everyone “ we are not doctors “ Frankly I think many of the regulars here SHOULD BE DOCTORS OR TEACHERS OF DOCTORS! To teach doctors how to be human and compassionate!
All of that said, I was looking for an explanation of the text he sent me about “ Only active in androgen receptor mutant patients with LBD mutation. You have ATM mutation only”
No doctor has EVER mentioned “ MUTATION “ ANYTHING! To this “ non doctor “ I can imagine that a “ mutation “ in some shape/form is responsible for my cancer. But I now expect to find an answer here more quickly than I will on the VA oncology clinic.
Today is my date for my monthly LUPRON shot. I don’t always get to see the oncologist assigned to me. I will ask if I can talk with him. I have more compassion for him than he has for me. But as “ my oncologist “ in my set of rules to be HUMAN I’m suppose to treat him with that special CARE. Although I can make him laugh when he least expects it I still don’t think that he sees the connection for treating him with a modicum of specialness that equates to making the glue that binds us different than what it is with others. And I hate sounding petty but he has mentioned numerous times that I’m older than him and I LOOK YOUNGER and I’m “ doing better “ ( no very specific explanation ) he texts me which his staff tells me that he’s never done even with Staff. So I think that my sense of humor has loosened him up some. Specifically was the day I gave him a pep talk saying “ we’re in this together Doc and I put my arm around his shoulders and gave him a hug “ that’s when he gave me an unexpected chuckle that made him choke a little as he swallowed unexpectedly and I patted him on his back as my Grandma used to do to me whenever I choked on something I was drinking saying “ something went down the wrong pipe “ which made him laugh harder.
I’m not sure he remembers that but we’ll see today. I have a doctor joke for him.
All of that said, can you explain him “MUTANT” comment?
Much thanks Jeff!

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Replies to "Thanks Jeff for your comprehensive reply including your comments on bipolar ( beside my prostate cancer..."

ATM is the genetic disorder. I have BRCA2 another genetic disorder.

This comment “ Only active in androgen receptor mutant patients with LBD mutation. You have ATM mutation only” is referring to the fact that you don’t have an LBD mutation, you only have an ATM mutation so the first part of the sentence doesn’t apply to you.

You are correct though. An ATM mutation increases the risk of developing prostate cancer, particularly more aggressive and lethal forms, and is associated with earlier onset of the disease. You should spend some time searching the web for information on ATM so that you are informed.

I do not understand why your doctor is giving you one month Lupron shots. I had six month shots for six years, I know a lot of people that get three month shots. I don’t know anybody that gets one month shots regularly, If you aren’t in Canada, this would be a real profit making adventure for your doctor. I can think of no logical reason you could not get at least a three month shot. You should ask your doctor about this, why you’re getting one month shots when you don’t need to come back every month.