Has anyone gone off hormone therapy (ADT) after radiation?

My partner quit ADT, Orgovyx, after 9 months of the 2 years the docs wanted him to do. He felt like it was too risky to be on it longer than that, health wise. He was already getting heart palpitations and of course all the other terrible side effects. He stopped in January, and so far his PSA has remained steady. Background: He's stage 3, initial PSA of 92, heavy tumor burden, and he did 40 sessions of VMAT radiation.

There is quite a bit of discussion about so-called intermittent ADT.
You might google the subject "intermittent ADT"searching it thru AI on Google

Your husband might also wish to consider joining this clinical trial headed by Dr Ravi Madan SENIOR Clinician at NIH/NCI. I'm in it and it's still recruiting.
It's at the NIH in Bethesda, MD but they cover transportation costs. Your husband's doctor would still be the lead dog on the sled and would get all the test and imaging results if he wishes, as would your husband.

Here's the info

Prospective Monitoring of Subjects With Biochemically Recurrent Prostate Cancer Using 18FDCFPyL

ClinicalTrials.gov ID NCT05588128

Sponsor National Cancer Institute (NCI)

Information provided by National Institutes of Health Clinical Center (CC) (National Cancer Institute

Google this for his recent update
Asco 2025: Prospective Monitoring of PSMA–positive Biochemically Recurrent Prostate Cancer: Preliminary Data from 6-Month PSMA Follow-Up

Hi, just finished SBRT about 6 weeks ago while doing ADT since February. I was 4+3 and cancer was pretty aggressive. My radiation was 5 sessions for the prostate and 3 for the hip bone. My PSA just prior to radiation was 0.19 and as of yesterday it was undetectable.
I've been on white button mushrooms for the past month and a half after reading clinical trial results from multiple places. I believe it helped to reduce my PSA and it looks like I'll be doing this maybe forever as long as my PSA remains where it is. I'm also taking CBD oil as there have been studies that it has a good effect on prostate cancer.
Good luck all. Dave

Here is information I gathered:
http://www.researchgate.net/publication/276923472_A_phase_I_trial_of_mushroom_powder_in_patients_with_biochemically_recurrent_prostate_cancer_Roles_of_cytokines_and_myeloid-derived_suppressor_cells_for_Agaricus_bisporus_-induced_prostate-specific_ant
https://www.emjreviews.com/en-us/amj/oncology/news/white-button-mushrooms-found-to-halt-cancer-progression/
https://www.researchgate.net/publication/384813429_Reduction_of_myeloid-derived_suppressor_cells_in_prostate_cancer_murine_models_and_patients_following_white_button_mushroom_treatment
https://www.healio.com/news/hematology-oncology/20250121/mushroom-supplement-may-slow-prostate-cancer-progression

Thank you very much for your reply.
It is my understanding that Orgovyx doesn't stay in the system as long as the other medications.

Thank you so much for this information. However, we are Canadians, so it would be difficult and most likely, impossible to be included in this clinical trial. I truly appreciate you sharing the information.

Jim, which ADT did you take? I’m in my ninth month of Orgovyx and the side effects are severe. I’m also 74, and my team wants me to be on ADT two years. Aarrgghhh!

I’m also on my 9th month of Orgovyx but have had little of the severe side effects. Loss of libido, some fatigue but not anything debilitating. I swim every day and that seems to keep a lid on more severe effects. I guess everyone’s body responds differently.

Unfortunately, with my Gleason 8, it is unlikely they’ll want me off ADT for at least another year. I’m looking closely at the discussions around intermittent ADT. I think it makes a lot of sense, but will continue to monitor and probe the issue with my RO. These next two weeks I start my PT. Glad it’s here.