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Endometrial Cancer Stage IIIC1

Gynecologic Cancers | Last Active: 50 minutes ago | Replies (54)

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Is the tumor MMR proficient (pMMR) and p53 abnormal? I assume it wasn't tested for POLE?

I had a stage 1B (85% myometrium invasion) Grade 3 endometrioid tumor that was pMMR and p53 abnormal. No tumor in lymph nodes. I had 6 cycles of carboplatin/paclitaxel plus vaginal brachytherapy. The cancer recurred, spread throughout my abdomen, in less than a year. This is something that you want to do everything possible to avoid.

I wish I had had carbo/taxol plus EBRT. Carbo/taxol is definitely no fun, but it's tolerable. I've had a total of 14 cycles. During the first 6, I mostly stayed home, but during the second 8 (after the recurrence), I went out and enjoyed life during the second and third weeks of each cycle. (The first week is pretty miserable.). I didn't have EBRT, but that would undoubtedly make you feel worse.

I didn't realize it at the time, but right after surgery was my only opportunity for EBRT. People who have a recurrence as a single tumor, say in the vaginal cuff, are given radiation after recurrence. But I wasn't eligible for radiation after recurrence, since I had tumors throughout my peritoneum.

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Replies to "Is the tumor MMR proficient (pMMR) and p53 abnormal? I assume it wasn't tested for POLE?..."

How soon did you get the recurrence? In 2017 I had Serous Papillary cancer Grade 2- had same chemo as you and brachytherapy -Got through it all- did not react to chemo badly-only first 4 days of each cycle- and total hair loss. Weird things occured-tinnitis, severe itching in rectum, and sometimes severe stomach cramps- managed it all. Fast forward, My oncologist said just get yearly check ups with primary GYN- discovered it early with salmon colored staining and then blood in urine. Hope all goes well with you..

What is EBRT

Thank you for your response. I'm so sorry to hear that the recurrence happened so quickly.
I'm still deciding what to do before my consult with the medical oncologist.

I'm not really sure about the pMMR and P53.
My pathology report says pMMR, ER positive, p53 wild type.