What would you do if PSA stayed at 0.15 after prostatectomy?
Hi everyone,
I am 58 years old. I had a radical prostatectomy seven months ago and my PSA never dropped to undetectable levels. It has stayed at 0.15 for the past three months.
One doctor recommends a conservative approach with low dose radiation to the prostate bed only. Another recommends a more aggressive plan with radiation to the prostate bed, glands, and lymph nodes along with hormone therapy (relugolix for 6 to 18 months).
I am torn between avoiding side effects now versus hitting it hard to lower long term risk. Has anyone here faced this decision? How did you choose, and do you feel it was the right call?
Thanks for any insight. I would really appreciate hearing your experiences.
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It would be good to get your pathology report; if you did not have clear margins or had C cells in the seminal vesicles, that can impact your decision. My husband's prostatectomy was 4 years ago and we were told he didn't have clear margins, which means he had C cells on the surface of the prostate, but not that it had spread to the vesicles. His PSA two weeks ago was 0.11 and oncologists commonly look at 0.2 as the point of more treatment. However, that his C was outside his prostate changed everything; the oncologist said 0.11 understated and it was likely many times greater. Monday he starts 33 weekdays of radiation and 6 mo of hormone treatment (Degarelix). He is also getting genetic testing for BRAC1 and BRAC2 (increase prostate cancer risk in men). Cancer cells feed on sugar and testosterone/androgen so the hormone treatment stops production (manopause). He has to stop some antioxidants because they protect cells, even the evil ones (turmeric for example) and start calcium and vitamin D3 to retain bone density. Resistance/weight training is also important. He also starts ED meds because they increase blood flow, which has a protective effect on genitals. So much to learn.
As suggested else where I'd get your pathology report. To help you understand it, you may wish to Google AI all its information to get an explanation of all of its findings and then query your question.
Read all the caveats and click on the paper clip icons for the basis of the info
As to your doc's differences, it seems that based on what they've seen in the pathology report, the first one seems to believe that any of what is likely micrometasis that may have slipped out of the prostate is still limited to the prostate bed. The other one seems to be more conservative and is not taking the chance that it hasn't gone further. Hence more radiation to more areas (look up "involved field radiation") and is using ADT probably as a so-called sensitizer to improve the radiation (in layman lingo- it softens up the cancer)
Overall from what you've described, it seems like you're in good shape here irrespective of which treatment you take.
Good luck!!
I've never heard before that cancer feeds off sugar.
It feeds off everything - don’t concern yourself with sugar unless you use too much already.
If you only consume sugar naturally available in fruits, vegetables and have desserts in low to moderate amounts you will not be harming yourself at all.
Phil
Food we eat is converted to glucose, which is the energy source for our cells, and also for cancer cells. The reason oncologists and nephrologists recommend cutting down on sugar and other simple carbohydrates is more complex. Here is one link on that: https://news.cancerresearchuk.org/2023/08/16/sugar-and-cancer-what-you-need-to-know/
My PSA after surgery was 2.8 not good was very disappointed since Dr said we caught my cancer early . Was advised for 6 weeks if radiation 5 days a week then 2 hormone shots with Lupron 3 months apart . My PSA was .02 after radiation but was told long term results was shown in tests to be important. I wish I only agreed to one dose of Lupron, many side effects my last shot was April this year and I still have all the side effects, good luck
Whatever you do, I think you should look into taking Turkey Tail mushroom tea daily. It can kill prostate cancer stem cells . Do not rely on it as a stand-alone treatment. Only use it as an adjuvant.
Thank you for that article, @kayabbott - FINALLY a balanced, factual explanation of the sugar/cancer myth!
Like any thing else, too much sugar is not good for your body - PERIOD.
TJ - your situation is very similar to mine- darn similar . I got salvage radiation , 2 years after my operation- it worked well . Dropped me back from post op of 0.14 , to 0.031 almost immediately . No ADT unless ABSOLUTELY needed , in my opinion and that of my RO . My URO was is full agreement of no ADT and just 22 sessions of light radiation . It seemed to work for me . Both say I have now health prostate cells in the area producing small amounts of PSA - they are not worried about it . I elected to get 3 month PSA tests , my Urologist said yearly now is good , but is OK with every 3 months if it will calm my anxiety . Hope this helps
I’m curious. After your surgery, did your PSA stay consistent around 0.14? If so, what was the reason for waiting two years before starting salvage radiation? During that time, did your PSA remain stable or did it fluctuate?