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Why are urologists dismissive about Decipher?

Prostate Cancer | Last Active: Sep 13 12:48pm | Replies (60)

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My guess is that the experience you describe is related to your specific diagnosis and the follow-up treatment options that surgeons versus radiologists will offer. Decipher is of varying value in guiding treatment options, based on a man's Gleason score and his other clinical diagnosis specifics.

The Decipher test analyzes gene expression in tumor tissue to predict the risk of metastasis and prostate cancer-specific mortality.

Most references indicate that a Decipher score is best for guiding treatment recommendations in patients with intermediate-risk prostate cancer...Gleason 7...both 3+4 and 4+3.

A Decipher score for a man diagnosed with Gleason 7 can reclassify his risk (based on a Clinical/Genomic model) to better inform a treatment choice.

Active surveillance can be recommended for men with Gleason 3+4 and a low Decipher scores (< 0.45)...this was my situation.

Definitive therapy (surgery or radiation) may be a better choice for men with Gleason 7 men who have a Decipher score between 0.45–0.60.

Adding androgen deprivation therapy (ADT) to radiation, may be recommended for men with Gleason 4+3 and a high Decipher score (>0.60).

Decipher could provide value in high-risk men (Gleason 8–10), if longer-duration ADT or other escalations are being considered. However, its impact on changing treatment management, for Gleason 8-10 cases, is generally of limited value, since aggressive treatment is often standard.

In low-risk cases, men with Gleason 6, Decipher is usually of limited value, since active surveillance is typically recommended. Of course in certain high volume Gleason 6 it may be considered, if there's a suspicion of Gleason score undergrading.

Bottom Line: The Decipher score's value depends on how definitive your clinical results are in determining your best treatment option(s). I'm glad I had it done, as it was a key piece of information guiding my decision to start AS.

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Replies to "My guess is that the experience you describe is related to your specific diagnosis and the..."

Excellent post - we are glad my husband hat it one as well. Our urologist administers the Lupron (I should say the NP administers it). But our oncologist leads the team a she developed the plan of action with the urologist a radiologist. We see her every three months for blood tests an an exam.