Maybe I am misunderstanding the PSE. I thought it combined PSA level and a PC epigenetic marker to improve the likelihood that a "positive" test is actually associated with the presence of cancer. (94 vs 50 % accuracy?) Does it actually provide information about the severity/aggressiveness of the predicted cancer? I thought its main purpose was to help men decide whether or not to have a biopsy for the first time. If someone already knows cancer is present, from a prior biopsy, how does the PSE help. None of the articles I have access to explain this.