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Transperineal vs Transrectal biopsy

Prostate Cancer | Last Active: Sep 5 4:14pm | Replies (51)

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I don't think that transperineal is the standard in the USA, yet. I was not offered it in Tucson - a fairly large and progressive city. In fact, researching Mayo Arizona, I found that they claim to be one of the few centers (of excellence!) in Arizona that offers the transperineal biopsy. I am scheduled for transrectal biopsy next week - MRI fusion-guided - because that is what my urologist offers. I will see a Mayo Clinic doctor for consultation and consideration of unique focal treatment in late October, which is the first appointment available. The Mayo doctor said to keep my appointment and get the biopsy done now, then send pathology report to him. I was "freaking out" about this topic until I saw a great, detailed presentation by urologist, Dr. Michael Ahdoot on YouTube. His presentation helped me understand and relax. You should see it!!! https://youtu.be/bK1ozkOgatw?si=Hy1DrRFDWweg8rIz

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Replies to "I don't think that transperineal is the standard in the USA, yet. I was not offered..."

Thanks for sharing the video. For those interested here is the link to the published article from the randomized trial described. Bottom line is that the difference in the risk of infection between the two procedures is not statistically significant if appropriate antibiotic prophylaxis is used with transrectal procedures (antibiotics are not needed with the transperineal procedure) and the diagnostic yield statistically equivalent. Best to go with your Urologist's experience and recommendations as both procedures have value. Transperineal biopsies may ultimately become the procedure of choice primarily due to concerns regarding emergence of antibiotic resistant bacteria:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11976521/
And this article documents the diagnostic yield from TR vs TP approach:
https://pmc.ncbi.nlm.nih.gov/articles/PMC9883893/pdf/12894_2023_Article_1176.pdf