Connect
← Return to Migraines and depression and anxiety
Discussion
Migraines and depression and anxiety
Headache & Migraine | Last Active: Sep 12, 2025 | Replies (12)Comment receiving replies
I have been on Zoloft for years. It has never helped to relieve my migraines.
Replies to "I have been on Zoloft for years. It has never helped to relieve my migraines."
Connect
Welcome to Mayo Clinic Connect, @ln2e.
You mentioned that sertraline (Zoloft) didn't relieve your migraines. Was it prescribed for your migraines, depression or another condition? Did something else work for relieving your migraines at all?