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Management of ADT hot flashes?

Prostate Cancer | Last Active: Sep 28 9:59am | Replies (18)

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True, ADT doesn’t directly cause hot flashes. Basically, ADT (androgen deprivation therapy) hormone therapy leads to the pituitary gland downregulating its response resulting in a decrease in testosterone from the testicles. (See attached diagram,) This decrease in testosterone has significant metabolic side-effects, including (unfortunately) hot flashes. (Note that testosterone is an “androgen.”)

Lupron is an ADT (along with Eligard, Prostap, Camcevi, Lucrin, Zoladex, Trelstar, Pamorelin, Decapeptyl, Firmagon, and Orgovyx.)

Abiraterone (Zytiga) is not an ADT, Though it is a hormone therapy, it’s actually an ARPI (androgen receptor pathway inhibitor) - along with Erleada (apalutimide), Xtandi (enzalutimide), and Nubeqa (darolutamide).

Prednisone is a steroid used to control cortisol levels that are affected by the Abiraterone (Zytiga).

Depending on what your baseline testosterone level was, and how long you were on ADT, they say to not expect full recovery from the side-effects for 50% longer than you were on ADT. (Some men never fully recover depending on their age and how many years they were on ADT.). There are documented ways to minimize the side-effects of hormone therapy - including the hot flashes - without using other pharmaceuticals.

You mentioned bone loss. Did you have a baseline DEXA scan prior to start treatments?

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Replies to "True, ADT doesn’t directly cause hot flashes. Basically, ADT (androgen deprivation therapy) hormone therapy leads to..."

Yes, I did have a DEXA scan which showed bone loss. I think that your 50% of time to recover from ADT is correct, at least for me. Six years ago I was on ADT for six months and it took three months after discontinuing for my testosterone to get up to 400. This time, I was on ADT for three years and am now eleven months off. My testosterone is now 100 and I am hopeful that it will return to normal in seven months. I hope that the side effects stop a long time before my PSA goes up.