Welcome to Mayo Clinic Connect, @loresull.

I personally was prescribed semaglutide (Wegovy) and lost 53 pounds. However, I had really challenging gastrointestinal side effects and finally asked my doctor about switching to tirzepatide (Zepbound). My husband, meanwhile, started the semaglutide (Wegovy) as well. He had no GI side effects and lost around 30 pounds on it before hitting his insurance cap for coverage of weight loss shots. He's since gained back 20 pounds.

In retrospect, switching weight loss shots was a mistake for me, mostly due to running into an insurance cap for weight loss medications and losing time. I hit this cap right about the time I got to the highest tirzepatide dose, as I had to start at the bottom dose and work up to the highest one. The tirzepatide did not suppress my appetite like the semaglutide did, which was crystal clear. I also had not lost more than 1 pound on it before I got to the insurance cap. This seemed odd, as I'd understood tirzepatide to be more effective than semaglutide. But it didn't turn out that way in my case.

In order to test to see if the semaglutide was causing my GI distress, I had to be off all weight loss shots for a month. Then, as I mentioned, I had to start all over with the tirzepatide. All this led to my gaining back 24 pounds. Super frustrating.

All this is to say that one's response to these weight loss shots appears to be highly individual. I would consult with your doctor and look at the best plan for you with any medical insurance caps you may have for weight loss shots very much in mind.

What does your doctor recommend you do at this point, loresull?