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Next steps for metastatic low volume
Prostate Cancer | Last Active: Sep 5 1:37pm | Replies (10)Comment receiving replies
Hi Jeff, I've heard it can take 18-24 month post radiation to reach your nadir. I had SRT and 18 months of ADT (Orgovyx + Abiraterone). The SRT concluded in May of 2024 and the ADT concluded in June of 2025. My PSA was undetectable for 9-12 months. One month after cessation of ADT my PSA was 0.054. It climbed for a couple of weeks up to 0.065 on July 28. It has been declining since and was 0.04 last week. I'm thinking that the initial climb was due to the complete elimination of the ADT effects and that the subsequent declines are due to the continuing SRT effects. Have you ever heard of PSA declining all the way to undetectable for someone in my situation? As background I was diagnosed was diagnosed in August 2021, RP in September 2021, GS 8, stage Pt3b.
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It is quite common for a PSA to bounce around a little bit, especially after treatment. That .04 sounds great. Don’t be afraid if it bounces around a Little, You’ve already seen that can happen.
3 1/2 years after surgery, my PSA started rising, so I had salvage radiation. They gave me a six month ADT shot before the salvage radiation. My PSA stayed undetectable for 2 1/2 years before it started rising again (I have BRCA2 so Recurrence is normal). So yes, Your PSA can become undetectable after treatment like you describe.
Forgot to mention that the standard they go by is if your PSA is < .1 you are considered undetectable.