As others have shared here, the fact so many felt fine before the infusion but have experienced musculoskeletal pain since makes for a cause and effect argument. For 18 months after my infusion, I have had flare ups that mostly involve my right leg and can last for weeks or even months. When the time came to have my 2nd infusion, I declined. I am hoping it will work itself out of my body but it has caused issues that will remain as I have not been able to be as active as before. The flareups have affected my quality of life and yes, have been depressing. It's a good sign that your pain is easing and maybe you can put off your decision for a bit longer. My Dr. calls it a drug holiday even though I only had one dose. I don't intend to take it again. I wish you the best.