Al, the liver plays a key role in PSA production and clearance.
According to Courtney Lawhn Heath, MD, Radiologist, UCSF, San Francisco, CA common false positives and the limitations of treating PSMA PET as a straightforward diagnostic tool for prostate cancer.
It would be unusual for metastatic prostate cancer to appear first in the liver.
I'm responding without experience. The knowing gentlemen will follow.