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Next steps for metastatic low volume

Prostate Cancer | Last Active: Sep 5 1:37pm | Replies (10)

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It’s hard to believe they would have 20 sessions of radiation and not hit that bone mets. One of the most common things is to get the bone mets radiated, Especially before they spread more and cause issues with your bone marrow. After radiation, the PSA drops very slowly so yours is pretty normal, Some people take up to three years for it to drop to the lowest point.

With the low PSA you have it’s unlikely that they will find anything with a PSMA Pet scan. Ask the radiation oncologist if you can get your bone mets zapped with SBRT radiation.

I got prostate cancer at 62. My brother got it at 75.. My father died from it, Which doubles the chance of my brother and I getting it. I got BRCA2 from my mother and along with my father‘s prostate cancer I got it younger than my brother. My brother didn’t have BRCA2 and that was why his prostate cancer came later.

What I’m getting at is that your brother and you should get a genetic test to find out if there is A genetic reason why he got it so much younger. There could be BRCA2 in your family, and that means every one of the Cousins brothers, sisters, and children should be tested. That’s what happened in my family when I was diagnosed with it. One of my aunts died of breast cancer, as did her daughter at 60. Another aunt got it, but survived and died of something else. This is way before they were able to detect BRCA2. We definitely got it from my grandfather who died of pancreatic cancer at 46.

You can both get it done free with the below link, if you live in the United States. Do not check the box that you want your doctor involved or they won’t send you the kit until they get in contact with your doctor. It takes about three weeks to get the results and then a genetic counselor will call you.
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Prostatecancerpromise.org

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Replies to "It’s hard to believe they would have 20 sessions of radiation and not hit that bone..."

Hard to believe but still common. Some clinics and doctors aren't up to date with the latest doublet and triplet approaches to treating metastatic prostate cancer (or they do know, and just aren't convinced yet).

In 2021 (at a Regional Cancer Centre affiliated with a university and big urban teaching hospital), they radiated my spinal metastasis even before they did the prostate itself. I didn't know anything about this stuff at the time — things were happening fast — so I'm lucky they did.

Hi Jeff, I've heard it can take 18-24 month post radiation to reach your nadir. I had SRT and 18 months of ADT (Orgovyx + Abiraterone). The SRT concluded in May of 2024 and the ADT concluded in June of 2025. My PSA was undetectable for 9-12 months. One month after cessation of ADT my PSA was 0.054. It climbed for a couple of weeks up to 0.065 on July 28. It has been declining since and was 0.04 last week. I'm thinking that the initial climb was due to the complete elimination of the ADT effects and that the subsequent declines are due to the continuing SRT effects. Have you ever heard of PSA declining all the way to undetectable for someone in my situation? As background I was diagnosed was diagnosed in August 2021, RP in September 2021, GS 8, stage Pt3b.