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Last PSA Number Before Cancer Diagnosis?

Prostate Cancer | Last Active: Sep 3, 2025 | Replies (94)

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My PSA hit 4.8 when my PCP referred me to a urologist who performed a biopsy. Cancer in two cores, Gleason 6. Surveillance recommended. A few months later I went for a second opinion and a second biopsy. More cancer was found that was Gleason 7 (3+4). Now a candidate for treatment. Most significant to me (and the urologist) was my very linear PSA velocity from several years of testing (see attached plot). As the second urologist said, 'we can treat now, or wait, but I guarantee you will be back for treatment within a year'. I opted for a robotic radical prostatectomy with him ASAP. No regrets, although ten years later I now have recurrent cancer with PSA of 0.1 and a palpable lesion in the prostatic fossa, and no evidence of metastatic disease on PET or MRI scans. Starting EBRT of prostate bed and pelvic lymphs nodes in mid September.

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Replies to "My PSA hit 4.8 when my PCP referred me to a urologist who performed a biopsy...."

It doesn’t matter if most of Your Gleason Score was 3+4, what was the highest Gleason score they found? That is the only one that counts and your treatment depends on that score not what most of them were.

The chance of reoccurrence is based on that higher score, And you definitely have had reoccurrence if they found a palpable lesion in the prostatic fossa. I had radiation when my PSA hit .2 3 1/2 years after surgery but they didn’t see any metastasis yet.

The PSMA pet scan can’t see lesions smaller than 2 1/2 mm and According to a UCSF radiologist even 5 mm is hard to see. Your radiologist is definitely telling you that sooner is better. It doesn’t make sense to let it grow for another year because it can spread.