It means metastatic castrate resistant prostate cancer. When your PSA starts rising, even though you’re on ADT, you are considered castrate resistant. It usually requires you be on an ARSI drug (Zytiga or a lutamide) In order to get your PSA to come back down.

Some people become castrate resistant CRPC Without being metastatic yet. The ARSI Drugs can keep the PSA down and slow down the growth of metastasis. Unfortunately, it usually is a matter of time before metastasis start appearing, For me, it was a couple years after I became CRPC Before a metastasis appeared on my spine. I was on an ARSI But the metastasis still showed up.