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Pancreatic Cancer Surgery Q&A w/ Dr. Stauffer on September 4
Pancreatic Cancer | Last Active: Sep 7, 2025 | Replies (33)Comment receiving replies
There is an excellent clinical trial finder at TriCanHealth.com. You can look up the different trials for the specific KRAS mutation and it explains the mode of action. There are several KRAS trials using drugs such as RMC-6236 which is a pan KRAS inhibitor drug. It has the ability to target a wide number of KRAS variants whereas drugs line RMC-9805 and MRTX-1133 target a specific KRAS mutation-in this case G12D. Some trials combine drugs to see if a synergistic effect is obtained. An example is a trial by Revolution Medicine combining RMC-6236 and RMC-9805 to see if enhanced efficacy is achieved over monotherapy with either drug. In the trial descriptor using TriCanHealth.com or clinicaltrials.gov, there will be a section describing mode of action and trial objective.
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The RMC-6236 is closed at Huntsman in Utah (close to where we live) and waiting for data and hopefully FDA approval. My husband is on Gem-Abr now, but it may not be working. He had to go off folfirinox because it may have been what was causing him to have bleeding ulcers. He had never had ulcers before. The other KRAS trials seem to be targeting specific mutations. His is KRAS G12V. But, we are trying to stay researching. My husband and I have stayed super active and eat a pretty strict diet. He is also trying intermittent fasting, which seems to be helping with energy.