Can the chance of nerve sparing be assessed from MRI images?

Posted by animate @animate, Aug 29, 2025

Should my Urologist be able to provide a prediction on whether nerves could be spared during my RALP, based on the MRI images and the location of tumors identified in the Biopsy, along with PSA, PIRADS and Gleason values?

I understand that nothing is definite until the Surgeon actually sees what the situation is like during the procedure but could he be able to assess, within certain degree of confidence, what we might expect based on these studies?

So far he only went through the MRI interpretation report with me, which only shows a very general sketch of the tumor location, but he has not gone through the actual MRI captured images with me to explain what he is seeing. Should I be asking him to review these images with me?

Thank you.

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Profile picture for brianjarvis @brianjarvis

Actually, the technology today is so much improved these days. MRI, bone, and CT scans are called “conventional imaging” while PSMA PET scans are called “next generation imaging.”

Dr. Johnson (of Mayo Clinic) talks about the value of all these in his presentation, starting with the scans we’ve all heard about (MRI, bone, & CT scans), and then going into detail about PSMA PET scans at: https://youtu.be/JoJomACA5UM

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A PSMA scan found a metastasis on my L4.. Before they would radiate it, the radiation oncologist required that an MRI be done so they could more closely figure what area need to be zapped.

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Profile picture for jeff Marchi @jeffmarc

A PSMA scan found a metastasis on my L4.. Before they would radiate it, the radiation oncologist required that an MRI be done so they could more closely figure what area need to be zapped.

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Yes, as support for PSMA PET scans, MRIs can find hidden lesions - like between the prostate and bladder as just one example. Or in your case, to look for what other tissues are near the L4 lesion to be avoided.

But, what an MRI would see as a just a lesion, a PSMA PET scan can differentiate between prostate cancer or not (which is why MRI-guided biopsies are done).

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Are you more interested in nerve sparing or wide clean margins? Just a thought as prostates in many cases leak cells that get left behind.

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Profile picture for chippydoo @chippydoo

Are you more interested in nerve sparing or wide clean margins? Just a thought as prostates in many cases leak cells that get left behind.

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At a PCRI conference earlier in the year

Drs Kwon and Moyad agree to this. Seeds for metastasis were already there when surgery was done, waiting to grow.

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Hopefully that was the cause of my BCR and radiation got it. Time will tell.

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