Thank you for responding. Since my last post I have experienced skin eruptions around my mouth and bone pain, none of which I had the past 5 years on Prolia. I did more research and found that the half life of denosumab is 26 days, so, it will take almost a month before even 50% of this drug is cleared from my system. I also read that it peaks in 10 days. My last post was before the 10 day mark and that may have factored into the additional side effects I am experiencing. I wonder if Sutter is getting the drug at a phenomenally reduced price as they are using their patients for post marketing statistics, the stage 4 trial of a new drug. Once again, thank you for your response. I am a breast cancer survivor and appreciate the new fact I learned that Prolia has anti-bone tumor properties. That kind of makes me reconsider trying Prolia, again, in 6 months, rather than switching to fosamax.