I’m sorry your first injection was so painful. I’ve had four now and the amount of pain I’ve had during the injection has varied. The first stung a bit, the second was excruciating, the third was almost completely painless, and the fourth was painful only in one arm. I am not sure how long the medication sat out during the first two but I know it was out for at least fifteen minutes during the last two.

The third injection occurred at the end of an interview with the doctor so I suspect it had been out the longest. I agree with you that the temperature of the medication may be factor in how painful the injection is.