I just received my first set of Evenity injections. They were given in the back of my upper arms. The first injection was the most painful injection I have ever received and I've had biopsy injections for breast cancer, abdominal Lovenox injections, heparin Etc. The first arm was excruciating. I was actually screaming, trying to pull away and it took forever. It was so painful we waited a bit for the second arm and that wasn't nearly as bad and took half of the time. I suspect the Evenity hadn't sat out at all because the medical representative that did the injections told me when I came into the room that she needed to go get approval from the doctor to release the medication so I suspect it came out of refrigeration just before being injected. I appreciate the comments and insight here, based on what I've read I'm going to insist that the medication has sat out for at least 30 minutes before administered next month. I experienced absolutely no sight pain after the fact in either arm, so for that I'm grateful. Here's hoping next month is a better experience! Sending wishes for good health to all of you!