Side effects from Lyrica

Posted by westcom @westcom, Aug 13, 2023

Has anyone experienced balance issues as s side effect of Lyrica? I just increased dose to 100 mg 3x/day and suddenly feel weak and unbalanced.

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Profile picture for bajjerfan @bajjerfan

Seriously, are you taking 75 different meds? I'd be sitting down with pharmacist and try to weed out as many as possible. They are the ones who are supposed to know if what you're taking is compatible.

It seems from reading here that the lion's share of people who try Lyrica/PreGabalin can't seem to tolerate it. I switched cold turkey from GabaPentin to Lyrica. Other than ED no real side effects from Lyrica and it helps me considerably more than GabaPentin did. I don't think I could do without it now.

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I agree, Lyrica much better than Gabapentin for neuropathy.
Just started on Lyrica almost a month ago.

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Profile picture for margaret10 @margaret10

I've been trying to get off Lyrica for years because I didn't feel that it wasn't doing much in terms of helping my chronic pain (neuropathy, lower back pain). At one point I had edged down to 25 mg/d, but the pain was agonizing, so I went back up to 100 mg/d, which barely took the edge off. I'm back down now to 18 mg/d and having loads of pain, much more than I had years ago when I first got on Lyrica. A complicating factor is that if I go off cold turkey, I know from experience that I'll have seizures. Regardless, I really want to get off it because, not only does it not help much with pain, but it also massively increases my weight, brain fog and exhaustion. I keep trying to find another way to control the pain. Opioids are out - in the long term, they make the pain worse. I'm trying out low-dose naltrexone, but it seems I may be allergic to it - jury is out on that. Most maddening of all is that, despite barking up many trees, we still don't know what the underlying disease is that is causing my nerve pain. I've been diagnosed with mitochondrial dysfunction, adrenal insufficiency (Addison's disease) and am heterozygous for SDHB and FBXL4, but none of these is sufficient evidence for my doctors to conclude that we have found the cause of my nerve damage. Without a cause, trying to find an effective treatment is very difficult.
I'd love to hear how you progress in your quest to get off Lyrica.

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Another poster stated that LDN “shuts down your adrenal glands for 3 hours.” I am taking 5mg of Prednisone to restart my adrenal function after 60mg daily for 8 months and then a taper for Interstitial Lung Disease. It’s been recommended that I start LDN and now I’m conflicted. Any thoughts from anyone? Thank you!

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I'm not clear on the sequence of drugs for you, and your current disease state. Are you currently taking LDN and/or prednisone? Do you currently have neuropathy, and if so, is the cause known (genetic, viral, injury, autoimmune, diabetic)? Do you currently have interstitial lung disease? Have you been diagnosed with mitochondrial dysfunction or oxidative stress? Do you have a neuromuscular neurologist and/or mitochondrial disease specialist? Lyrica was bad for me because I gained 50 lbs, experienced bad brain fog, and did not get much relief from my pain, but some people say it helps their pain.

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For me Lyrica was not as bad as Gabapentin but still had some brain fog. And it too was not very effective against the tingling of neuropathy in my feet. I found that Cymbalta was the only one of the 3 common PN drugs that did not cause brain fog. But it does have other side effects and is not that helpful so I don't take any of them now.
Topical CBD creams seem to do just as well as any of the prescription drugs for relief of PN. Here is one that I use daily. https://www.swansonvitamins.com/p/swanson-ultra-cbd-full-spectrum-balm-mint-150-mg-2-oz-balm

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Yes it's terrible. I want to get my body stronger so I can try to get off it some day!! I'm on the 100mg x 3 daily dose also. I am sensitive and typically feel when it wears off. It causes similar symptoms as narcotic pain relievers. You get rebound pain when medicine wears off. I'm not a fan of this medicine however, it does help severe nerve pain quite a bit.

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I have recently had a rather strange experience with Lyrica. This is a "restricted drug" in my state of California, not sure about other places but have not heard it mentioned here. Was only allowed enough medication for 28 days at a time. Have been taking it for 2-3 years with gradual increases from my doctor over time. Was taking only 50mg 2 at night 1 in daytime and it really helped my pain & functionality a lot! About 6 months after the last increase, I noticed I was hurting more so, on my own, I increased my dosage to 2 in daytime as an experiment & it helped but it meant I would come up short at end of the time period. I thought my doctor would just write another script for what I needed but she refused. Even refused to give me an alternative. Perhaps she was also restricted, I don't know. The result was that I was forced to "cold turkey" rather than taper off this medication for a few days. With the help of lots of Acetaminophen & sleeping pills I made it through. When I finally got my medication back, my doctor did increase it to 200mg per day, but I am still having trouble getting back to feeling very well. I am 85 years old but otherwise in good health, the only other prescription I take is for blood pressure, I do supplement with B12, ALA & magnesium. Hopefully my body will eventually adjust.

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Has anyone experienced burning on their head from Lyrica?

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Profile picture for snatwick @snatwick

Has anyone experienced burning on their head from Lyrica?

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Welcome @snatwick, You are not alone. Other members have mentioned the burning and Lyrica. Here's is a search link with the discussions and comments - https://connect.mayoclinic.org/search/?search=head+burning+%2Blyrica.

Have you been diagnosed with a form of neuropathy?

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Profile picture for John, Volunteer Mentor @johnbishop

Welcome @snatwick, You are not alone. Other members have mentioned the burning and Lyrica. Here's is a search link with the discussions and comments - https://connect.mayoclinic.org/search/?search=head+burning+%2Blyrica.

Have you been diagnosed with a form of neuropathy?

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@johnbishop yes, I was shot with a .22 in my spinal cord L4 and L5 and I have had a spinal and neck fusion and as a result of the spine damage my left leg is atrophy drop foot and partial paralysis. I have feeling in it. I've had my left foot and leg reconstructed twice due to a ankle break and several other surgeries on it. Including having my akiles tendon stretched cut and sown back together for my foot to set flat. Bones removed from my foot and screws and brackets inserted in my foot and ankle. My leg and foot turns purple blue and splochy red. I have burning. Stabing throwing pains in my foot ankle leg and back. Pins and needles alot too. I was recently put on Lyrica because I wasn't getting relief from Gabapenton. But the side effects swelling and dizziness and burning in my head.

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I also was dependent on opiates for the last 30 years. My accident was when I was 12. I finally got off of them all in October. I have been using cannibas for pain relief.

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