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Polymyalgia Rheumatica (PMR) | Last Active: Aug 31, 2025 | Replies (20)
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It seems like prednisone slows down your metabolism and also causes your body to store more fat, so you don't need to eat as much as before. I noticed that my metabolism got back to normal as I dropped down to 2 mg and lower. It took me a while to get used to eating like I used to, but I'm enjoying it now.
Replies to "It seems like prednisone slows down your metabolism and also causes your body to store more..."
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Prednisone mobilizes your reserves while depleting muscles and bones. It increases the circulating blood glucose level that might be needed if there was an emergency. However, when there isn’t the emergency the body expects, the excess glucose gets stored as fat.
It is all part of the “fight or flight” response to stressful events when cortisol is supposed to be released. When there is circulating prednisone all the time we are in a constant fight or flight state. However, we sit around in pain and do nothing to burn the glucose. Our entire metabolic processes get out of whack.
I think the insatiable hunger while on prednisone happens when the body tries to build up its reserves but we are still on prednisone. Everything we eat gets stored as fat and isn’t metabolized correctly.