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Does anyone have a solution to help manage Reclast side effects?
Osteoporosis & Bone Health | Last Active: 5 days ago | Replies (579)Comment receiving replies
I had terrible reactions to the Reclast and reported it to the FDA but nothing seems to be done about this horrible drug. I found a good Functional Medicine doctor. She started me on several supplements including mineral drops, HRT, Ozone therapy, red light therapy, etc. It was a 9 month program and very expensive but I'm much better today. I've read a lot and have watched YouTube videos about the Dexa Scan and the diagnosis or osteoporosis. I would suggest this to others. I have made the decision to NEVER take anything else for the treatment of osteoporosis. The more you learn, the more you know. I'm 73 year old and have never broken a bone.
Replies to "I had terrible reactions to the Reclast and reported it to the FDA but nothing seems..."
Well unfortunately I did break a bone. And sort of in the midst of all this big mess back I guess it's close to 8 years ago now I fell and shattered my elbow into pieces that is what led me to the forteo. I did not seem to have any problems with that drug but then after a year and a half I have my own hearing loss and it seems have been connected. I think I shared all that before. I just said you went to a functional medicine doctor? Is that like an integrative medicine doctor? We have an integrative center not for me I May check out and actually an integrative doctor which means somebody who has a medical degree and practice is medicine as well as some of the more natural things so I may look into one of those individuals? I don't know anything about these things that you're mentioning if you have any information you could pass on to me I would appreciate it. Thank you
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ikhender, a physician described:
"When amino-bisphosphonates (N-BPs) [Reclast] are administered IV, resulting in a high systemic exposure (unlike when taken orally, where the very low oral bioavailability results in a quite low systemic exposure), phagocytic cells other than just osteoclasts can encounter the N-BP, Up to 30% of patients can experience an APR (acute phase reaction) after their initial infusion of zoledronic acid. This APR, which starts usually about 6 hours post-infusion, and can last several days, consists of a mild fever associated with muscle and joint pains, similar to the symptoms with a bad viral infection such as the flu. And it turns out that the cause is very similar, as well. When a special category of phagocytic T-cells, called gamma-delta T-cells, encounter the zoledronic acid, they engulf it, just like an osteoclast will engulf alendronate or zoledronic bound to the bone surface. And just like an osteoclast that engulfs a N_BP undergoes apoptosis cell death, the gamma-delta T-cells that engulfs a N-BP also undergoes apoptosis. The difference is, when a gamma-delta T-cell undergoes apoptosis, it releases inflammatory cytokines, such as IL-1, IL-6, and TNF-alpha, just like when it encounters a flu virus. And these inflammatory cytokines mediate the temperature rise and myalgias."
He didn't explain about the possibility of the effect lasting a year or more. There is the 146 hour half life. But the positive feedback loop that causes a severe, systemic inflammatory response can make it self sustaining.
I think the IV steroid can break the cycle. Was it even temporarily effective for you?