Hi @brad331, and welcome to Mayo Clinic Connect! I am glad you found this discussion to share your Repatha experience with. I am hopeful you will find encouragement here.

Repatha did not work for me and I currently take inclisiran. I was initially told it worked the same way as Repatha but my experience is totally different, so I know it doesn’t. I ended up in a circulation crisis a few years ago and my doctors are working with me, addressing symptoms one at a time. I had other health issues prior to taking Repatha, more following, so I’m not quite sure I can directly speak to side effects of the drug. Some of what you describe does seems familiar to me.

I want to invite @rhondaj to meet you because she has described some similar problems. Also, you may want to check out another discussion if you have not already:
- Repatha, side effects, and what comes next?: https://connect.mayoclinic.org/discussion/repatha-and-side-effects/

I am learning to function better by staying highly active, resistance training and maintaining a strict diet. For whatever reason I need to be extremely consistent with all of it. I am interested to hear as you learn, so please do post more.

You mention your lifestyle has been wrecked. What things are you not able to do now? What is your next step?