I got 6 Month Lupron shots for almost seven years. Then I switched to Orgovyx for the last 2 years. All ADT. As soon as I became castrate resistant, they put me on an ARSI as well.

I had a 3+4 Gleason and had surgery. After surgery, it was a 4+3, but it did not spread anywhere outside the prostate. It came back 3 1/2 years later and I had radiation. They gave me my first 6 month Lupron shot before radiation and I never really even noticed Any side effects. I stayed undetectable for 2 1/2 more years and then it came back again. At that point, 9 years ago, they put me on ADT I have BRCA2, Which is why it keeps coming back.

A 72 PSA With lymph node involvement is higher risk! It’s no wonder you are on four years of Lupron. Once the cancer gets to your lymph nodes, it’s in your bloodstream and can spread anywhere. That’s why the continued Lupron, It prevents growth and spread.

Something to be concerned about is staying on only Lupron for so long. If your husband became castrate resistant, that could shorten his overall survival. I became castrate resistance 2 1/2 years after taking Lupron, which is the average?. Once you become castrate resistant, the median survival is two years. For me that was six years ago, way beyond the median, But I started off with a low PSA and no spread.

They have now found that if you are on ADT taking an ARSI Can greatly delay the time Until castrate resistance. If you do some searches, you can confirm what I’m saying. It might make sense to ask your doctor to put you on an ARSI. The easiest one on the body is Nubeqa. That could Delay time to castrate resistance. As long as he’s been on ADT, it could happen anytime so you wanna try to delay it. Zytiga could also delay it, But it comes with lots of side effects.