Hello @mompiano, Welcome to Mayo Clinic Connect. PMR can definitely keep a person from doing pretty much anything when the disease is active and you are in pain. It took me 3-1/2 years to taper off of prednisone for my first occurrence of PMR and 1-1/2 years the second time. My rheumatologist did tell me that a small percentage of people are not able to taper completely off and do keep taking a smaller dosage. You mentioned you have been trying to wean off of prednisone this past year. When were you diagnosed with PMR and started on prednisone?