My experience has been wildly variable after each injection. First injection I did not have much joint or muscle pain. Second shot I had pain that started a few days after and lasted about a week. Third shot the pain started immediately and lasted two weeks. I had my fourth shot last Friday and initially had very little joint or muscle pain (and even posted that yesterday). Unfortunately, five days after my shot my right hip and knee started hurting, enough to wake me last night.

I take two extended release Tylenol every night at bedtime. This lasts about six hours but then I am awakened by pain.

So, my experience is that it seems to be different every time. I am sticking with the medication, though, in the hopes of it helping me build bone. The pain and disability I had following my compression fracture was much worse and if Evenity helps me avoid another fracture then I am willing to put up with the discomfort.