It is established standard of care to be on Abiraterone and prednisone and Lupron. They kept my husband's Stage 4 MCRPC suppressed for over three years. HOWEVER, there are other medications you can take instead of Lupron which have the same benefit if its side effects are terrible for you. Please ask your oncologist or whoever prescribed Lupron for an alternative. You don't need to be miserable or take chances with recurrence.