Good question. I noted it in my biopsy report, and my physician didn't even address it (I forgot to ask him while there for the post-biopsy appointment). In my follow-up pre-op appointment, and in my post-op surgical pathology report review, I asked both times about PNI. My urologist said, with a near-flippant tone: "don't worry about it, everyone has some degree of PNI, it doesn't mean anything to the bigger picture." So...if there are any physicians following this conversation, please weigh-in on your opinion of the significance of PNI and how it impacts any outcome or treatment plan.