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Lupron yeah or Lupron nay that is the question.
Prostate Cancer | Last Active: Sep 29 10:51am | Replies (112)Comment receiving replies
So far I have only had one Lupron shot with Abiraterone/Presidone and am due for another shot next month. Before starting with Lupron my PSA was 0.03. I had 24 radiation treatments four years ago (diagnosed with a Gleason 9) and now the cancer has metastasized to my bones again. One spot on my spine which came back after it was radiated a year ago, and a tiny spot on my pelvis. I never felt any discomfort or pain until I was put on Lupron. Now I am in constant pain every minute of every day and I can barely function. I'm afraid another shot of Lupron will put me in a wheelchair for the rest of my life.
Replies to "So far I have only had one Lupron shot with Abiraterone/Presidone and am due for another..."
The problem with the pain is probably not just Lupron. If you started Lupron without having Biclutamide (Casodex) for the first two weeks, then you will get flares that can cause pain. That would be a mistake made by your doctor.
Once you’ve passed the first shot, the flares pretty much stop. It’s more likely that the pain is bone pain from metastasis. This is something you really need to discuss with your doctor to find out what it could be. Adding an ARSI might benefit you in more than one way, You could reduce the chance of early castrate resistance, And it would be more effective in reducing bone metastasis, and pain.
Lupron can reduce your Bone density and that can cause problems. At a recent conference, a bone doctor talked about the fact that anybody on ADT should be on bone strengtheners, which can help with Increasing bone density. I was on Fosamax For the first six years, I was on Lupron and then switched over to Zometa. It is kept my bones strong and I’ve never had a problem with pain even though it was on Lupron for over six years and now Orgovyx.
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It is established standard of care to be on Abiraterone and prednisone and Lupron. They kept my husband's Stage 4 MCRPC suppressed for over three years. HOWEVER, there are other medications you can take instead of Lupron which have the same benefit if its side effects are terrible for you. Please ask your oncologist or whoever prescribed Lupron for an alternative. You don't need to be miserable or take chances with recurrence.