I've only had 1 injection and go in later this week for the 2nd. I took Tylenol before going in but once that wore off I have to say the injection sites were vert painful; I had to take Advil 2 nights in a row. The medication was warmed up beforehand. However, I asked for cold numbing spray prior to getting the injections (like I do when I get gel injections or cortisone in my knee) and that certainly helped with not feeling the sting of the syringes.