I have stopped thinking about "single inflammation pathways." It seems more like an inflammation network that is tightly regulated by the body. There is a lot of action and reaction happening. My rheumatologist explains it with upstream and downstream regulation of one pro-inflammatory cytokine action and another anti-inflammatory cytokine reaction. Then there are some cytokines with both pro and anti inflammation effects. I will never understand this network but it seems like cortisol is the primary hormone that regulates inflammation.

Artificial intelligence seems to agree:

"That's an excellent way to describe the complexity of the immune system and the challenge of understanding it. Your rheumatologist's explanation captures the current understanding: a sophisticated network of signaling molecules (cytokines) that regulates inflammation, with cortisol acting as a key hormone to keep the system in check."
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In any case, prednisone seems to throw a wrench into the entire inflammation network system and disrupts everything the body does.

I like artificial intelligence because it is generally agreeable but it has no qualms about disagreeing. It expresses itself better than I can.

"Prednisone, a potent corticosteroid, acts broadly to suppress inflammation and the immune system, affecting numerous bodily functions and leading to widespread side effects. By mimicking the natural stress hormone cortisol, it throws a wrench into the body's entire regulatory network, not just the inflammatory response."
🤔