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If you have tapering problems below 5 mg this might explain why.
Polymyalgia Rheumatica (PMR) | Last Active: Sep 10 10:38am | Replies (110)Comment receiving replies
I wasn't enrolled in this study but my experience with Actemra mirrors the results of the study. No reason to believe that Kevzara wouldn't work for some people as well but maybe not everyone.
Replies to "I wasn't enrolled in this study but my experience with Actemra mirrors the results of the..."
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Actemra and Kevzara both inhibit IL-6, so both should help with PMR for some people. I'm starting to understand that IL-6 is an inflammatory substance and also an inflammation controller. If a drug inhibits IL-6, it also inhibits other sources of inflammation that are controlled by IL-6. Inhibiting IL-6 is both good and bad for people with PMR and GCA. It reduces the autoimmune response that is attacking the body's tissues, but it also reduces the body's immune response against infections and vaccines. I've read that people vary as to how much of their inflammation is generated by IL-6 vs other inflammation pathways, so that determines if Actemra or Kevzara will be effective against their disease.