Some people would say Kevzara does nothing to directly improve your cortisol level if you have prednisone induced adrenal insufficiency. I would say there is an indirect effect that helps.

Hopefully, Actemra or Kevzara will allow you to taper your Prednisone dose to 3 mg and still prevent a flare of PMR. Being able to stay on 3 mg was the magic dose that allowed my cortisol level to improve. That 3 mg dose of prednisone was a low enough dose for my adrenals to get a strong signal to produce cortisol again.

Adrenal insufficiency from long term prednisone use can persist for a long time. My endocrinologist told me to be prepared to stay on 3 mg of prednisone for "as long as it takes" for my cortisol level to improve. I was only able to stay on 3 mg of prednisone without a flare of PMR because of Actemra. In my case, my cortisol level improved after 6 months. For some people it won't be that long but for other people it might be much longer. I felt awful on 3 mg of prednisone but at least I didn't have a PMR flare.

What usually happens, is that patients taper their prednisone dose lower only to have a flare of PMR. The dose of prednisone at which flares happen is disproportionately around 7 mg which is approximately the dose where our bodies can sense a low cortisol level. Typically a flare of PMR happens and prednisone is increased only to suppress adrenal function some more. Without Actemra, I would never have been able to maintain a 3 mg dose long enough to allow my adrenals to recover some of their function.

After I stopped Prednisone and remained on Actemra alone, my adrenals made a full recovery. The advantage that Actemra and Kevzara have over Prednisone is that these medications can control PMR and GCA without suppressing adrenal function.

The "prednisone deal with the devil" we make happens when our adrenal function gets suppressed. In essence, we replace cortisol with prednisone. The deal results in adrenal suppression and it is difficult to undo this deal.

Artificial intelligence says the following:
"The idea of the "prednisone deal with the devil" is a metaphor for the serious risk of adrenal suppression that comes with corticosteroid use. When you take prednisone, a powerful synthetic steroid, your body no longer needs to produce its own natural stress hormone, cortisol. This effectively "replaces" your natural cortisol with the drug."
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Unfortunately, adrenal insufficiency is the devil we live with when we take long term prednisone..