Anyone taking Nubeqa (darolutamide) have a problem with constipation?

Posted by asolidrock @asolidrock, Aug 24, 2025

I just started getting constipated; I'm on nubeqa. Has anyone here on nubeqa that has gotten constipated.

Thanks

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Profile picture for jeff Marchi @jeffmarc

Nubeqa is not causing those hot flashes. They only occur when you have low testosterone, and Nubeqa will not reduce your testosterone at all, It works quite well, even with high testosterone.

If you don’t believe me do some searches on the web it will convince you that you are incorrect about this.

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So what would be causing them? I sweat at the drop of a hat. Well I'm new to all this and I'm not trying to question u because you know a hundred times more than me

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Profile picture for asolidrock @asolidrock

So what would be causing them? I sweat at the drop of a hat. Well I'm new to all this and I'm not trying to question u because you know a hundred times more than me

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You are on ADT. It usually reduces testosterone to below 5. That’s what causes the hot flashes. Even if you stopped ADT, it would take a while before your testosterone would come back and stop the hot flashes.

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Profile picture for jeff Marchi @jeffmarc

You are on ADT. It usually reduces testosterone to below 5. That’s what causes the hot flashes. Even if you stopped ADT, it would take a while before your testosterone would come back and stop the hot flashes.

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So you talking about the elegard shots

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Profile picture for asolidrock @asolidrock

So you talking about the elegard shots

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No Orgovyx is ADT. As are the following drugs.

Firmagon, Lupron, Eligard, Prostap, Camcevi, Lucrin, Zoladex, Trelstar, Pamorelin, and Decapeptyl

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Profile picture for asolidrock @asolidrock

So you talking about the elegard shots

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Oops. Glad I included all the drugs. I was trying to do too many things at the same time.

I missread your comment as Erleada, Eligard is ADT.

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Profile picture for jeff Marchi @jeffmarc

Oops. Glad I included all the drugs. I was trying to do too many things at the same time.

I missread your comment as Erleada, Eligard is ADT.

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Heck I live in Southern Louisiana and everybody sweats here it's so humid

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Profile picture for asolidrock @asolidrock

Heck I live in Southern Louisiana and everybody sweats here it's so humid

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I live in Southern Louisiana also about 35 miles fromNew Orleans; it does get hundreds loving the cooler weather.

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I do not have any constipation issues. I was a zofran for a while and did not drink enough water. I became so compacted I had to go to the emergency room. Luckily a fleet worked but I destroyed the bathroom. It was the worst. I also do not have a gall bladder and when I eat too much fat I get very loose stool. Stay hydrated. I have never heard that Nubeqa can cause constipation.

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I have been on Nubeqa for 7 months and other ADT for longer. Never have constipation, but I eat a lot of fiber and hydrate a lot and exercise, which I would think would help.

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Watch your blood ALT numbers with Nubeqa. Mine were good throughout a six course of Docetaxel, then the number shot up to 155. ( range should be 0-41.

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