"In the neoadjuvant setting, Kato et al. explored the impact of neoadjuvant androgen deprivation therapy (ADT) in high-risk PCa patients with concurrent IDC-P [43]. They retrospectively analyzed 145 patients post-RP, stratifying them into three groups: IDC-P-negative, IDC-P-positive with disappearance post-ADT, and IDC-P-positive with persistence post-ADT. Interestingly, around 28% of IDC-P-positive cases responded to ADT, exhibiting the complete disappearance of IDC-P at RP and demonstrating comparable overall survival to IDC-P-negative cases. Conversely, the remaining 72% with persistent IDC-P showed the worst prognosis, with a hazard ratio of 3.84 compared to IDC-P-negative cases. "

I really do not understand why all of the findings and research mean nothing until they become "standard of care" which may happen never or 15 years later when it is meaningless for patients that are having a problem NOW .

The whole process of PC treatment is "up to a patient" anyways, so why those patients do not have a right to try some individualized approach with signing non liability papers for doctors ?! Why, for example, my husband was never informed of neoadjuvant approach for IDC ? Adding ADT before treatment is definitely not unheard of approach nor controversial in any shape or form . Here would be no harm done and he would possibly even have his IDC completely disappear before RP !

The more I learn about what could have been done for my husband and was not , the more depressing it is becoming. It is one thing when one just has a bad luck end ends with difficult situation and the whole another level of unfortunate when that situation was preventable or helped in significant way but was not 😢.