I am taking 25 mg. I tried the low dose but the compound was too expensive as Big Pharma does not make anything lower than 25 mg. It has helped me a lot AFTER I take it. I wake up with the post exertion malaise and fatigue and just poisoned feeling. After I take my medications, I can function for most of the day but I do crash in the late afternoon and evenings. I will take what I can get. I hope it works for you!