I self injected forteo for two years and never had a problem. Then I was put on fosamax but had to go off b/c of high b/p. My doctor said if I ever broke a bone (I have had a few minor falls, tripping over toys, the dog, etc. but luckily have never broken a bone) and my doctor said if I ever did break a bone I'd have to go off the Prolia and she would most likely prescribe Evenity. But the heart related issues scare me away from that direction. Maybe I'll take the old fashion, tried and true fosamax and then take a blood pressure medicine to counter act it.