Hi Roger, that's a great question. My thinking is that the dose should give you relief from pain until the next dose. I know everyone is different but it just seems logical to my non-medically trained mind☺ I've heard of some folks splitting the dosage and taking some in the morning and some at bedtime but I would discuss it with the doctor. I don't think there are any cut and dried rules when tapering down on prednisone. If it were me and I was taking 10 mg daily each morning and felt good until bedtime, I might try taking 8 or 9 mg in the morning and 1 or 2 mg at bedtime. I would still ask the doc though.