Comment receiving replies
Replies to "I saw a RO yesterday and discussed all treatment options noted above. For my situation, he..."
Well, RO’s are always gonna have a radiologically based treatment plan; but as Jeff indicates, cribriform is not always responsive to radiation - even HDR…and it could return leaving you no salvage radiation option.
I think your age is pretty important here, as well as your overall health.
If you are ‘young’ - early 70’s or less and in good health I think surgery might be a better option (distasteful as that sounds). You’ve got probably 10+ yrs to get recurrence.
However, if you are over 75 and/or have comorbidities then radiation makes more sense. Bluntly, with apologies, you’ll probably die from something else before the PCa recurs.
Brachytherapy has been discussed as one of the options used to really eliminate Cribriform. I know that in at least one other case they first had IMRT then brachytherapy.
You could discuss this combination with the doctor to see if it might be more effective.
From this AI search. “ can imrt followed by brachytherapy be used to eliminate cribriform”
A combination of Intensity-Modulated Radiation Therapy (IMRT) and brachytherapy is a viable treatment option for prostate cancer with cribriform features. This aggressive combination is often used for higher-risk cancers, such as those with cribriform patterns, to increase the radiation dose to the tumor while minimizing side effects.
If you do that search yourself, you will find a lot more information than this one Paragraph.