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Can Prostate Cancer "Take a New Trajectory"?

Prostate Cancer | Last Active: Aug 29 6:50am | Replies (46)

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My situation is similar. Since both Gleason and Decipher were high, Ive had prostatectomy + radiation + 2 1/2 years ADT. My PSA has been < 0.01-- but you never know. I've been off ADT for just 5 weeks. First PSA since coming up next month.

Given my cancer is high risk, I just can't understand why the Drs would want me to come off ADT. Why take the chances "just to see what happens"? Make zero sense to me.

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Replies to "My situation is similar. Since both Gleason and Decipher were high, Ive had prostatectomy + radiation..."

Yes, it's a difficult and personal choice. IMO, the main reason people sometimes become castrate resistant when they're on ADT and ARSI long term is that the castrate-sensitive cancer was prevented from spreading much earlier (which would have been worse; you don't want any cancer forming new metastases). 😕

After 2-1/2 years the Drs probably wanted to see if they've successfully stopped any growth. They'd rather you not go through the side effects, of ADT, any longer than necessary. Testosterone levels can be another signal. Three years after stopping ADT, my T level was 425. Urologist said that tells him that the fairly high T level was not feeding anything, since my PSA was still < .001. An ongoing guessing game, perhaps? I hope you go years and years without any recurrence.