I am not diabetic or even pre-diabetic and have struggled with neuropathy for over five years. Back in March I was put on doxycycline for a respitory condition and it has helped my neuropathy. I still have neuropathy, but the pain level is now down to a lvl 2, it has been as high as a 6. The doxy also resolved the burning sensation in my legs and seems to be helping my night sweats as well. All doctors involved agree that it is the anti-inflammatory portion of the doxy and not the antibiotic characteristic that is helping. I also have PMR and have been on prednisolone long term and that didn't touch the inflammation that the doxy is addressing. Hope this helps.